Curated Information
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PubMed Id: 11031258 
Sattler M, et al. (2001) SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL. J Biol Chem 276, 2451-8 11031258
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y918-p - SHIP (mouse)
Orthologous residues
SHIP (human): Y915‑p, SHIP (mouse): Y918‑p, SHIP (rat): Y917‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor')
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Dok1 (mouse) Induces co-immunoprecipitation, electrophoretic visualization
Shc1 (mouse) Induces co-immunoprecipitation, electrophoretic visualization

Y1021-p - SHIP (mouse)
Orthologous residues
SHIP (human): Y1022‑p, SHIP (mouse): Y1021‑p, SHIP (rat): Y1020‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor')
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Dok1 (mouse) Induces co-immunoprecipitation, electrophoretic visualization
Shc1 (mouse) Induces co-immunoprecipitation, electrophoretic visualization


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