|
Orthologous residues
|
|
PDE4A (human): S145‑p, PDE4A iso2 (human): S119‑p, PDE4A iso6 (human): S84‑p, PDE4A iso7 (human): S123‑p, PDE4A (mouse): S140‑p, PDE4A (rat): S140‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
COS (fibroblast)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
monkey
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
IBMX, forskolin
|
|
|
|
increase
|
|
|
H-89
|
forskolin, IBMX
|
|
|
inhibit treatment-induced increase
|
|
|
|
|
