Curated Information
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Curated Information Page
PubMed Id: 18836453 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Chen W, et al. (2008) Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol 15, 1213-20 18836453
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S435-p - IRF5 (human) ▲
Orthologous residues
IRF5 (human): S435‑p, IRF5 (mouse): S434‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  E.coli (bacterial)
 Cellular systems studied:  cell lines
 Species studied:  bacteria
Downstream Regulation
 Effect of modification (function):  activation

S437-p - IRF5 (human) ▲
Orthologous residues
IRF5 (human): S437‑p, IRF5 (mouse): S436‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  E.coli (bacterial)
 Cellular systems studied:  cell lines
 Species studied:  bacteria
Downstream Regulation
 Effect of modification (function):  activation

S440-p - IRF5 (human) ▲
Orthologous residues
IRF5 (human): S440‑p, IRF5 (mouse): S439‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  E.coli (bacterial)
 Cellular systems studied:  cell lines
 Species studied:  bacteria
Downstream Regulation
 Effect of modification (function):  activation, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CBP (human) Induces in vitro

S446-p - IRF5 (human) ▲
Orthologous residues
IRF5 (human): S446‑p, IRF5 (mouse): S445‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  E.coli (bacterial)
 Cellular systems studied:  cell lines
 Species studied:  bacteria
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein stabilization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CBP (human) Induces in vitro
 Comments:  stabilization of dimer


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