Curated Information
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Curated Information Page
PubMed Id: 18408713 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Degterev A, et al. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4, 313-21 18408713
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S6-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S6‑p, RIPK1 (mouse): S6‑p, RIPK1 (rat): S6‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S14-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S14‑p, RIPK1 (mouse): S14‑p, RIPK1 (rat): S14‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
 Comments:  autophosphoryation

S15-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S15‑p, RIPK1 (mouse): S15‑p, RIPK1 (rat): D15‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
 Comments:  autophosphoryation

S20-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S20‑p, RIPK1 (mouse): K20‑p, RIPK1 (rat): R20‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
 Comments:  autophosphoryation

S25-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S25‑p, RIPK1 (mouse): S25‑p, RIPK1 (rat): S25‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S161-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S161‑p, RIPK1 (mouse): S161‑p, RIPK1 (rat): S161‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
 Comments:  autophosphoryation
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  necroptosis regulation

S166-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S166‑p, RIPK1 (mouse): S166‑p, RIPK1 (rat): S166‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE RIPK1 (human)
 Comments:  autophosphoryation

S303-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S303‑p, RIPK1 (mouse): S304‑p, RIPK1 (rat): S303‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S320-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S320‑p, RIPK1 (mouse): S321‑p, RIPK1 (rat): S320‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S330-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S330‑p, RIPK1 (mouse): P331‑p, RIPK1 (rat): P330‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S331-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S331‑p, RIPK1 (mouse): S332‑p, RIPK1 (rat): S331‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S333-p - RIPK1 (human)
Orthologous residues
RIPK1 (human): S333‑p, RIPK1 (mouse): S334‑p, RIPK1 (rat): S333‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  leukemia, T cell leukemia
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human


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