Curated Information
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Curated Information Page
PubMed Id: 22748319 
Smyth JT, et al. (2012) Phosphoregulation of STIM1 Leads to Exclusion of the Endoplasmic Reticulum from the Mitotic Spindle. Curr Biol 22, 1487-93 22748319
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S628-p - STIM1 (human)
Orthologous residues
STIM1 (human): S628‑p, STIM1 (mouse): S628‑p, STIM1 (rat): S628‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
EB1 (human) Disrupts co-immunoprecipitation
 Comments:  phosphorylation dissociates STIM1 from EB1 during mitosis, and excludes ER from the mitotic spindle

S668-p - STIM1 (human)
Orthologous residues
STIM1 (human): S668‑p, STIM1 (mouse): S668‑p, STIM1 (rat): S668‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
EB1 (human) Disrupts co-immunoprecipitation
 Comments:  phosphorylation dissociates STIM1 from EB1 during mitosis, and excludes ER from the mitotic spindle


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