Curated Information

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Curated Information Page

PubMed Id: 14502288

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Wang J, et al. (2003) Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci 6, 1039-47 14502288

S1232-p - NMDAR2A (rat)

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Orthologous residues

NMDAR2A (human): S1232‑p, NMDAR2A (mouse): S1232‑p, NMDAR2A (rat): S1232‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal, CA1 pyramidal'-brain [CDK5 (rat)], 'neuron, hippocampal, CA1 pyramidal'-brain [NMDAR2A (rat)]

Cellular systems studied: tissue

Species studied: rat

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	CDK5 (rat)	genetic transfer of dominant-negative enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ischemia				increase

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