Curated Information
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Curated Information Page
PubMed Id: 14502288 
Wang J, et al. (2003) Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci 6, 1039-47 14502288
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S1232-p - NMDAR2A (rat)
Orthologous residues
NMDAR2A (human): S1232‑p, NMDAR2A (mouse): S1232‑p, NMDAR2A (rat): S1232‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal, CA1 pyramidal'-brain [CDK5 (rat)], 'neuron, hippocampal, CA1 pyramidal'-brain [NMDAR2A (rat)]
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK5 (rat) genetic transfer of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ischemia increase


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