Curated Information

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Curated Information Page

PubMed Id: 7537734

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Tracy S, van der Geer P, Hunter T (1995) The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane. J Biol Chem 270, 10587-94 7537734

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S180-p - PTPRA (mouse)

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Orthologous residues

PTPRA (human): S189‑p, PTPRA iso2 (human): S180‑p, PTPRA (mouse): S180‑p, PTPRA (rat): S183‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKCA (rat)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKCA (human)	pharmacological activator of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
phorbol ester				increase

S204-p - PTPRA (mouse)

▲

Orthologous residues

PTPRA (human): S213‑p, PTPRA iso2 (human): S204‑p, PTPRA (mouse): S204‑p, PTPRA (rat): S207‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site

Relevant cell lines - cell types - tissues: 293 (epithelial) [PTPRA (mouse)]

Cellular systems studied: cell lines

Species studied: human, mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKCA (rat)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKCA (human)	pharmacological activator of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
phorbol ester				increase

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