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Orthologous residues
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SNCA (human): S129‑p, SNCA (mouse): S129‑p, SNCA (rat): S129‑p
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Characterization
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Methods used to characterize site in vivo:
mass spectrometry, phospho-antibody
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Disease tissue studied:
Parkinson's disease
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Relevant cell lines - cell types - tissues:
cerebrospinal fluid
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Cellular systems studied:
tissue
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Species studied:
human
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Associated Diseases
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Diseases:
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Alterations:
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Comments:
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Parkinson's disease
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increased
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PD patients had higher S129 phosphorylation levels compared to healthy controls. Patients with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) patient, had lower S129 phosphorylation than PD patients or healthy controls. There was a weak correlation with P-S129 levels and severity of the PD.
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