Curated Information
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Curated Information Page
PubMed Id: 22344688 
Wang Y, et al. (2012) Phosphorylated α-synuclein in Parkinson's disease. Sci Transl Med 4, 121ra20 22344688
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S129-p - SNCA (human)
Orthologous residues
SNCA (human): S129‑p, SNCA (mouse): S129‑p, SNCA (rat): S129‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, phospho-antibody
 Disease tissue studied:  Parkinson's disease
 Relevant cell lines - cell types - tissues:  cerebrospinal fluid
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Parkinson's disease increased PD patients had higher S129 phosphorylation levels compared to healthy controls. Patients with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) patient, had lower S129 phosphorylation than PD patients or healthy controls. There was a weak correlation with P-S129 levels and severity of the PD.


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