Curated Information
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Curated Information Page
PubMed Id: 22695718 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Stolarczyk EI, et al. (2012) Casein Kinase 2α Regulates Multidrug Resistance-Associated Protein 1 Function via Phosphorylation of Thr249. Mol Pharmacol 82, 488-99 22695718
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T249-p - ABCC1 (human)
Orthologous residues
ABCC1 (human): T249‑p, ABCC1 (mouse): T249‑p, ABCC1 (rat): T249‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK2A1 (human) co-immunoprecipitation, siRNA inhibition of enzyme, modification site within consensus motif, phospho-antibody
Downstream Regulation
 Comments:  increase in ABCC1-dependent transport


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