Curated Information
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Curated Information Page
PubMed Id: 14517247 
Timm T, et al. (2003) MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22, 5090-101 14517247
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S262-p - Tau iso8 (human)
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p

T208-p - MARK2 (rat)
Orthologous residues
MARK2 (human): T208‑p, MARK2 iso4 (human): T208‑p, MARK2 iso10 (human): T175‑p, MARK2 iso11 (human): T208‑p, MARK2 iso13 (human): T175‑p, MARK2 iso14 (human): T175‑p, MARK2 (mouse): T208‑p, MARK2 iso3 (mouse): T208‑p, MARK2 (rat): T208‑p
 Enzymes shown to modify site in vitro
Type Enzyme
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S212-p - MARK2 (rat)
Orthologous residues
MARK2 (human): S212‑p, MARK2 iso4 (human): S212‑p, MARK2 iso10 (human): S179‑p, MARK2 iso11 (human): S212‑p, MARK2 iso13 (human): S179‑p, MARK2 iso14 (human): S179‑p, MARK2 (mouse): S212‑p, MARK2 iso3 (mouse): S212‑p, MARK2 (rat): S212‑p
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Comments:  A fraction of MARK in rat brain tissue is doubly phosphorylated at T208/S212.

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