Curated Information
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Curated Information Page
PubMed Id: 14517247 
Timm T, et al. (2003) MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22, 5090-101 14517247
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S262-p - Tau iso8 (human)
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p

T208-p - MARK2 (rat)
Orthologous residues
MARK2 (human): T208‑p, MARK2 iso4 (human): T208‑p, MARK2 iso10 (human): T175‑p, MARK2 iso13 (human): T175‑p, MARK2 iso14 (human): T175‑p, MARK2 (mouse): T208‑p, MARK2 iso3 (mouse): T208‑p, MARK2 (rat): T208‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE TAO1 (rat)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TAO1 (rat)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S212-p - MARK2 (rat)
Orthologous residues
MARK2 (human): S212‑p, MARK2 iso4 (human): S212‑p, MARK2 iso10 (human): S179‑p, MARK2 iso13 (human): S179‑p, MARK2 iso14 (human): S179‑p, MARK2 (mouse): S212‑p, MARK2 iso3 (mouse): S212‑p, MARK2 (rat): S212‑p
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Comments:  A fraction of MARK in rat brain tissue is doubly phosphorylated at T208/S212.


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