Curated Information
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Curated Information Page
PubMed Id: 9543386 
Peng CY, et al. (1998) C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ 9, 197-208 9543386
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S216-p - CDC25C (human)
Orthologous residues
CDC25C (human): S216‑p, CDC25C iso3 (human): S173‑p, CDC25C (mouse): , CDC25C (frog): S287‑p
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MARK3 (human)
 Comments:  MARK3 ubiquitously expressed in human tissues and cell lines.
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Induces
 Comments:  It is likely that multiple isoforms of 14-3-3 bound pS216 in the experiments described here.

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