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Orthologous residues
|
|
Pin1 (human): S138‑p, Pin1 (mouse): S140‑p, Pin1 (rat): S140‑p
|
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Characterization
|
|
Methods used to characterize site in vivo:
immunoprecipitation, mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
|
|
Disease tissue studied:
breast cancer
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial), 3T3 (fibroblast), breast, HeLa (cervical), MEF (fibroblast)
|
|
Cellular systems studied:
cell lines, tissue
|
|
Species studied:
human, mouse
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
MLK3 (human)
|
transfection of inactive enzyme, co-immunoprecipitation, transfection of wild-type enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
intracellular localization
|
|
Effect of modification (process):
cell cycle regulation
|
|
Associated Diseases
|
|
Diseases:
|
Alterations:
|
Comments:
|
|
breast cancer
|
increased
|
|
|
