Curated Information
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Curated Information Page
PubMed Id: 21828286 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rudrabhatla P, Jaffe H, Pant HC (2011) Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs. FASEB J 25, 3896-905 21828286
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S1396-p - MAP1B (human)
Orthologous residues
MAP1B (human): S1396‑p, MAP1B (mouse): S1391‑p, MAP1B (rat): S1388‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S1400-p - MAP1B (human)
Orthologous residues
MAP1B (human): S1400‑p, MAP1B (mouse): S1395‑p, MAP1B (rat): S1392‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S1779-p - MAP1B (human)
Orthologous residues
MAP1B (human): S1779‑p, MAP1B (mouse): S1775‑p, MAP1B (rat): S1770‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S1702-p - MAP2 (human)
Orthologous residues
MAP2 (human): S1702‑p, MAP2 iso2 (human): S346‑p, MAP2 iso3 (human): S1698‑p, MAP2 iso4 (human): S434‑p, MAP2 (mouse): S1703‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): S373‑p, MAP2 (rat): S1736‑p, MAP2 iso2 (rat): S1705‑p, MAP2 iso3 (rat): S342‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S1706-p - MAP2 (human)
Orthologous residues
MAP2 (human): S1706‑p, MAP2 iso2 (human): S350‑p, MAP2 iso3 (human): S1702‑p, MAP2 iso4 (human): S438‑p, MAP2 (mouse): S1707‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): S377‑p, MAP2 (rat): S1740‑p, MAP2 iso2 (rat): S1709‑p, MAP2 iso3 (rat): S346‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S948-p - NFH (human)
Orthologous residues
NFH (human): S948‑p, NFH (mouse): S1001‑p, NFH iso3 (mouse): S983‑p, NFH (rat): S983‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S33-p - NFM (human)
Orthologous residues
NFM (human): S33‑p, NFM (mouse): S33‑p, NFM (rat): S34‑p, NFM (chicken): S33‑p, NFM (cow): S33‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S685-p - NFM (human)
Orthologous residues
NFM (human): S685‑p, NFM (mouse): , NFM (rat): , NFM (chicken): , NFM (cow): S695‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S736-p - NFM (human)
Orthologous residues
NFM (human): S736‑p, NFM (mouse): S669‑p, NFM (rat): S667‑p, NFM (chicken): S688‑p, NFM (cow): S751‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T181-p - Tau iso8 (human)
Orthologous residues
Tau (human): T498‑p, Tau iso2 (human): T123‑p, Tau iso3 (human): T87‑p, Tau iso5 (human): T181‑p, Tau iso6 (human): T123‑p, Tau iso7 (human): T152‑p, Tau iso8 (human): T181‑p, Tau (mouse): T473‑p, Tau iso3 (mouse): T170‑p, Tau iso7 (mouse): T112‑p, Tau (rat): T492‑p, Tau (cow): T172‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S184-p - Tau iso8 (human)
Orthologous residues
Tau (human): S501‑p, Tau iso2 (human): S126‑p, Tau iso3 (human): S90‑p, Tau iso5 (human): S184‑p, Tau iso6 (human): S126‑p, Tau iso7 (human): S155‑p, Tau iso8 (human): S184‑p, Tau (mouse): G476‑p, Tau iso3 (mouse): G173‑p, Tau iso7 (mouse): G115‑p, Tau (rat): G495‑p, Tau (cow): S173‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S185-p - Tau iso8 (human)
Orthologous residues
Tau (human): S502‑p, Tau iso2 (human): S127‑p, Tau iso3 (human): S91‑p, Tau iso5 (human): S185‑p, Tau iso6 (human): S127‑p, Tau iso7 (human): S156‑p, Tau iso8 (human): S185‑p, Tau (mouse): S477‑p, Tau iso3 (mouse): S174‑p, Tau iso7 (mouse): S132‑p, Tau (rat): S496‑p, Tau (cow): S190‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T212-p - Tau iso8 (human)
Orthologous residues
Tau (human): T529‑p, Tau iso2 (human): T154‑p, Tau iso3 (human): T118‑p, Tau iso5 (human): T212‑p, Tau iso6 (human): T154‑p, Tau iso7 (human): T183‑p, Tau iso8 (human): T212‑p, Tau (mouse): T504‑p, Tau iso3 (mouse): T201‑p, Tau iso7 (mouse): T161‑p, Tau (rat): T523‑p, Tau (cow): T219‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T217-p - Tau iso8 (human)
Orthologous residues
Tau (human): T534‑p, Tau iso2 (human): T159‑p, Tau iso3 (human): T123‑p, Tau iso5 (human): T217‑p, Tau iso6 (human): T159‑p, Tau iso7 (human): T188‑p, Tau iso8 (human): T217‑p, Tau (mouse): T509‑p, Tau iso3 (mouse): T206‑p, Tau iso7 (mouse): T166‑p, Tau (rat): T528‑p, Tau (cow): T224‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T231-p - Tau iso8 (human)
Orthologous residues
Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S235-p - Tau iso8 (human)
Orthologous residues
Tau (human): S552‑p, Tau iso2 (human): S177‑p, Tau iso3 (human): S141‑p, Tau iso5 (human): S235‑p, Tau iso6 (human): S177‑p, Tau iso7 (human): S206‑p, Tau iso8 (human): S235‑p, Tau (mouse): S527‑p, Tau iso3 (mouse): S224‑p, Tau iso7 (mouse): S184‑p, Tau (rat): S546‑p, Tau (cow): S242‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S262-p - Tau iso8 (human)
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S396-p - Tau iso8 (human)
Orthologous residues
Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T403-p - Tau iso8 (human)
Orthologous residues
Tau (human): T720‑p, Tau iso2 (human): T314‑p, Tau iso3 (human): T278‑p, Tau iso5 (human): T372‑p, Tau iso6 (human): T345‑p, Tau iso7 (human): T374‑p, Tau iso8 (human): T403‑p, Tau (mouse): T695‑p, Tau iso3 (mouse): T392‑p, Tau iso7 (mouse): T352‑p, Tau (rat): T714‑p, Tau (cow): T410‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Comments:  neurofibrillary tangles
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased


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