Curated Information
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Curated Information Page
PubMed Id: 22510882 
Nakae J, et al. (2012) Novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J 31, 2275-95 22510882
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T93-p - FcoR (mouse)
Orthologous residues
FcoR (mouse): T93‑p
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), 3T3-F442A
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
H-89 forskolin inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  acetylation, intracellular localization
 Effect of modification (process):  transcription, inhibited
 Comments:  increases FoxoO1 acetylation and inhibits its transcriptional activity; suppresses expression of PGC-1alpha

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