Curated Information
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Curated Information Page
PubMed Id: 22474372 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wang F, et al. (2012) Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment. Proc Natl Acad Sci U S A 109, 6078-83 22474372
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S626-p - FOXO3A (human)
Orthologous residues
FOXO3A (human): S626‑p, FOXO3A (mouse): S625‑p, FOXO3A (rat): S625‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  293T (epithelial), HCT116 (intestinal), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CBP (human) zf-TAZ, KIX Induces NMR spectroscopy


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