Curated Information
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Curated Information Page
PubMed Id: 22195966 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ray-Gallet D, et al. (2011) Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell 44, 928-41 22195966
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1616-p - POLR2A (human)
Orthologous residues
POLR2A (human): S1616‑p, POLR2A var1 (human): S1616‑p, POLR2A (mouse): S1616‑p, POLR2A (rat): S1616‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, peptide sequencing, western blotting
 Disease tissue studied:  cervical cancer, cervical adenocarcinoma
 Relevant cell lines - cell types - tissues:  HeLa S3 (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
UBN1 (human) Induces transcription, induced co-immunoprecipitation
HIRA (human) Induces transcription, induced co-immunoprecipitation
CABIN1 (human) Induces transcription, induced co-immunoprecipitation
 Comments:  association of the HIRA complex (HIRA, Cabin1, and UBN1) with POLR2A

S1619-p - POLR2A (human)
Orthologous residues
POLR2A (human): S1619‑p, POLR2A var1 (human): S1619‑p, POLR2A (mouse): S1619‑p, POLR2A (rat): S1619‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, peptide sequencing, western blotting
 Disease tissue studied:  cervical cancer, cervical adenocarcinoma
 Relevant cell lines - cell types - tissues:  HeLa S3 (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
HIRA (human) Induces transcription, induced co-immunoprecipitation
UBN1 (human) Induces transcription, induced co-immunoprecipitation
CABIN1 (human) Induces transcription, induced co-immunoprecipitation
 Comments:  association of the HIRA complex (HIRA, Cabin1, and UBN1) with POLR2A


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