|
Orthologous residues
|
|
POLR2A (human): S1616‑p, POLR2A var1 (human): S1616‑p, POLR2A (mouse): S1616‑p, POLR2A (rat): S1616‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
immunoprecipitation, peptide sequencing, western blotting
|
|
Disease tissue studied:
cervical cancer, cervical adenocarcinoma
|
|
Relevant cell lines - cell types - tissues:
HeLa S3 (cervical)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
UBN1 (human)
|
|
Induces
|
|
transcription, induced
|
co-immunoprecipitation
|
|
CABIN1 (human)
|
|
Induces
|
|
transcription, induced
|
co-immunoprecipitation
|
|
HIRA (human)
|
|
Induces
|
|
transcription, induced
|
co-immunoprecipitation
|
|
|
Comments:
association of the HIRA complex (HIRA, Cabin1, and UBN1) with POLR2A
|
