Curated Information
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Curated Information Page
PubMed Id: 22153071 
Hatziapostolou M, et al. (2011) An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147, 1233-47 22153071
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y705-p - STAT3 (human)
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  hepatocyte
 Cellular systems studied:  cell lines, tissue
 Species studied:  human
 Comments:  hepatocellular carcinoma
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
miRNA HNF4 alpha (human) decrease miR-124 inhibition of HNF4F induces phosphorylation
HNF4 alpha (human) decrease HNF4 siRNA increases
miRNA increase miR-24
miRNA increase miR-629 (slight increase)
miRNA miRNA augment treatment-induced increase miR-24 + miR-629
Associated Diseases
Diseases: Alterations: Comments:
hepatocellular carcinoma increased


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