Curated Information
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Curated Information Page
PubMed Id: 22169477 
Krishnan N, Fu C, Pappin DJ, Tonks NK (2011) H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal 4, ra86 22169477
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S724-p - IRE1 (human)
Orthologous residues
IRE1 (human): S724‑p, IRE1 (mouse): S724‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
tunicamycin increase
CTH (human) no effect upon treatment-induced increase CTH shRNA -no effect on increase

Y419-p - Src (human)
Orthologous residues
Src (human): Y419‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
tunicamycin decrease
MSI-1436 decrease
MSI-1436 tunicamycin no effect upon treatment-induced decrease
tunicamycin CTH (human) increase CTH siRNA decrease
MSI-1436 CTH (human) increase CTH siRNA inhibits
MSI-1436, tunicamycin CTH (human) increase CTH siRNA inhibits

Y530-p - Src (human)
Orthologous residues
Src (human): Y530‑p, Src (mouse): Y535‑p, Src iso2 (mouse): Y529‑p, Src (rat): Y530‑p, Src (chicken): Y527‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
tunicamycin increase
MSI-1436 no change compared to control
MSI-1436 tunicamycin increase
tunicamycin CTH (human) increase slight increase
CTH (human) increase CTH shRNA inhibits
MSI-1436 CTH (human) increase
tunicamycin CTH (human) decrease CTH shRNA increase

Y615-p - PERK (mouse)
Orthologous residues
PERK (human): Y619‑p, PERK (mouse): Y615‑p, PERK (rat): Y611‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTP1B (human)


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