Curated Information
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PubMed Id: 22163037 
Chang F, et al. (2011) Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading. PLoS One 6, e28587 22163037
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y64-p - RAC1 (human)
Orthologous residues
RAC1 (human): Y64‑p, RAC1 iso2 (human): Y64‑p, RAC1 (mouse): Y64‑p, RAC1 (rat): Y64‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HUVEC (endothelial), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
KINASE FAK (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, inhibited
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ARHGEF7 (human) Disrupts co-immunoprecipitation
RhoGDI alpha (human) Induces co-immunoprecipitation
PAK1 (human) Disrupts co-immunoprecipitation
 Comments:  inhibits cell spreading


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