Curated Information
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Curated Information Page
PubMed Id: 22056988 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yang W, et al. (2011) Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 480, 118-22 22056988
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y333-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): Y333‑p, CTNNB1 (mouse): Y333‑p, CTNNB1 (rat): Y333‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma
 Relevant cell lines - cell types - tissues:  U87MG (glial) [EGFR (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  human glioblastoma specimens
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) mutation in upstream enzyme recognition motif, co-immunoprecipitation, activation of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  carcinogenesis, induced, cell cycle regulation, cell growth, induced, transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PKM2 (human) Induces co-immunoprecipitation
Associated Diseases
Diseases: Alterations: Comments:
glioblastoma increased

Y419-p - Src (human)
Orthologous residues
Src (human): Y419‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Disease tissue studied:  brain cancer, glioblastoma, glioma
 Relevant cell lines - cell types - tissues:  U87MG (glial)
 Cellular systems studied:  cell lines
 Species studied:  human


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