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Curated Information Page
PubMed Id: 22322096 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201 22322096
Only 100 sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Protein GeneSymb ACC# Organism MW (Da) RSD SiteGrpId Mod Type Site Sequence
4E-BP1 EIF4EBP1 Q13541 human 12,580 S44 3195716 Phosphorylation tPGGtLFsttPGGtR
A-Raf ARAF P10398 human 67,585 Y301 455521 Phosphorylation LGyRDsGyyWEVPPS
A6 TWF1 Q12792 human 40,283 Y309 450367 Phosphorylation ELTADFLyEEVHPKQ
ACTB ACTB P60709 human 41,737 T201 9425169 Phosphorylation tERGysFtttAEREI
Akt1 AKT1 P31749 human 55,686 T308 447856 Phosphorylation KDGAtMKtFCGtPEy
Akt1 AKT1 P31749 human 55,686 T479 8086741 Phosphorylation FsysAsGtA______
Akt2 AKT2 P31751 human 55,769 T306 5862778 Phosphorylation EGIsDGAtMKtFCGt
Akt3 AKT3 Q9Y243 human 55,775 T309 15407521 Phosphorylation tMKtFCGtPEyLAPE
Akt3 AKT3 Q9Y243 human 55,775 S472 447937 Phosphorylation RPHFPQFsysAsGRE
Akt3 AKT3 Q9Y243 human 55,775 Y473 15407515 Phosphorylation PHFPQFsysAsGRE_
AMPKA1 PRKAA1 Q13131 human 64,009 T183 448786 Phosphorylation sDGEFLRtsCGsPNy
AMPKA1 PRKAA1 Q13131 human 64,009 S184 3195152 Phosphorylation DGEFLRtsCGsPNyA
AMPKA1 PRKAA1 Q13131 human 64,009 S187 4169856 Phosphorylation FLRtsCGsPNyAAPE
ATF-2 ATF2 P15336 human 54,537 T69 448224 Phosphorylation sVIVADQtPtPtRFL
ATF-2 ATF2 P15336 human 54,537 T71 448225 Phosphorylation IVADQtPtPtRFLKN
AurA AURKA O14965 human 45,809 T292 15407960 Phosphorylation RRttLCGtLDYLPPE
AurB AURKB Q96GD4 human 39,311 T236 4164705 Phosphorylation RRKtMCGtLDYLPPE
B-Raf BRAF P15056 human 84,437 T440 447806 Phosphorylation EDRNRMKtLGRRDss
B-Raf BRAF P15056 human 84,437 S446 447804 Phosphorylation KtLGRRDssDDWEIP
BRD4 BRD4 O60885 human 152,219 T942 15408108 Phosphorylation LQKVQPPtPLLPSVK
CDK12 CDK12 Q9NYV4 human 164,155 T1244 455893 Phosphorylation GPQGPRRtPTMPQEE
CDK3 CDK3 Q00526 human 35,046 Y15 449490 Phosphorylation EkIGEGtyGVVyKAK
Chk1 CHEK1 O14757 human 54,434 S296 447832 Phosphorylation GFskHIQsNLDFsPV
Chk1 CHEK1 O14757 human 54,434 S317 447833 Phosphorylation ENVkYsssQPEPRTG
CLK3 CLK3 P49761 human 73,515 Y163 10855238 Phosphorylation RsPEPDPyLsyRWKR
CLK3 CLK3 P49761 human 73,515 S165 15408960 Phosphorylation PEPDPyLsyRWKRRR
CREB CREB1 P16220 human 36,688 S133 448228 Phosphorylation EILsRRPsyRkILND
DDR1 DDR1 Q08345 human 101,128 Y513 457956 Phosphorylation LLLSNPAyRLLLAty
DDR1 DDR1 Q08345 human 101,128 Y796 457957 Phosphorylation RNLyAGDyyRVQGRA
DYRK1B DYRK1B Q9Y463 human 69,198 Y273 449567 Phosphorylation LGQRIyQyIQsRFYR
EGFR EGFR P00533 human 134,277 Y998 452118 Phosphorylation sPtDsNFyRALMDEE
EphA5 EPHA5 P54756 human 114,803 Y650 455023 Phosphorylation KLPGVRtyIDPHTyE
EphB2 EPHB2 P29323 human 117,493 S575 449764 Phosphorylation RGFERADsEytDKLQ
EphB2 EPHB2 P29323 human 117,493 T590 10887908 Phosphorylation HytsGHMtPGMKIyI
ERK1 MAPK3 P27361 human 43,136 T202 447542 Phosphorylation HDHtGFLtEyVAtRW
ERK2 MAPK1 P28482 human 41,390 Y187 447594 Phosphorylation HtGFLtEyVAtRWyR
FAK PTK2 Q05397 human 119,233 S390 485785 Phosphorylation GMRtHAVsVsEtDDy
FAK PTK2 Q05397 human 119,233 Y576 447889 Phosphorylation RyMEDstyyKAsKGK
FNDC1 FNDC1 Q4ZHG4 human 205,558 S1319 15403544 Phosphorylation SRQPARPsyRQGYNG
FRK FRK P42685 human 58,254 Y497 451535 Phosphorylation YFETDssysDANNFI
GOLGA4 GOLGA4 Q13439 human 261,140 S40 4767666 Phosphorylation tRMRsRtssFtEQLD
GOLGA4 iso3 GOLGA4 NP_001166184 human 262,328 T43 4767672 Phosphorylation RSRtSsFtEQLDEGT
HGK MAP4K4 O95819 human 142,101 S523 22640994 Phosphorylation QEQAyLLsLQHDHRR
HGK MAP4K4 O95819 human 142,101 S913 4271620 Phosphorylation PtNTRPQsDtPEIRK
IGF1R IGF1R P08069 human 154,793 Y1166 448388 Phosphorylation DIyEtDyyRKGGKGL
IkB-alpha NFKBIA P25963 human 35,609 Y42 448737 Phosphorylation DsMkDEEyEQMVkEL
InsR INSR P06213 human 156,333 Y1189 447681 Phosphorylation RDIyEtDyyRKGGKG
InsR INSR P06213 human 156,333 Y1190 447682 Phosphorylation DIyEtDyyRKGGKGL
InsR INSR P06213 human 156,333 Y1355 447683 Phosphorylation sLGFkRsyEEHIPyt
InsR INSR P06213 human 156,333 T1362 15420319 Phosphorylation yEEHIPytHMNGGKK
IRS1 IRS1 P35568 human 131,591 S303 7832720 Phosphorylation QVGLTRRsRtEsItA
IRS1 IRS1 P35568 human 131,591 S312 447558 Phosphorylation tEsItAtsPAsMVGG
IRS1 IRS1 P35568 human 131,591 S616 447562 Phosphorylation DDGyMPMsPGVAPVP
JNK1 MAPK8 P45983 human 48,296 T183 447643 Phosphorylation AGtsFMMtPyVVtRY
JNK1 MAPK8 P45983 human 48,296 T188 4252620 Phosphorylation MMtPyVVtRYYRAPE
JNK3 MAPK10 P53779 human 52,585 T221 448034 Phosphorylation AGtsFMMtPyVVtRY
Jun JUN P05412 human 35,676 S73 447943 Phosphorylation VGLLKLAsPELERLI
KSR KSR1 Q8IVT5 human 102,032 S265 11005586 Phosphorylation LTPRALHsFItPPtt
KSR KSR1 Q8IVT5 human 102,032 T272 449298 Phosphorylation sFItPPttPQLRRHT
Lck LCK P06239 human 58,001 Y394 447822 Phosphorylation RLIEDNEytAREGAK
LRP6 LRP6 O75581 human 180,429 S1475 22639506 Phosphorylation ASSSSSsstKGtyFP
Lyn LYN P07948 human 58,574 Y397 448695 Phosphorylation RVIEDNEytAREGAK
MAPKAPK2 MAPKAPK2 P49137 human 45,568 T317 448272 Phosphorylation PTQRMTItEFMNHPW
MAPKAPK2 MAPKAPK2 P49137 human 45,568 T334 448273 Phosphorylation QstKVPQtPLHtsRV
MARK2 MARK2 Q7KZI7 human 87,911 S592 22640828 Phosphorylation TNFPRGVssRstFHA
MDM2 MDM2 Q00987 human 55,233 S166 448130 Phosphorylation SsRRRAIsEtEENsD
MEK1 MAP2K1 Q02750 human 43,439 S212 448283 Phosphorylation kLCDFGVsGQLIDsM
Mer MERTK Q12866 human 110,249 Y754 449990 Phosphorylation KIysGDyyRQGRIAK
Met MET P08581 human 155,541 T992 2428909 Phosphorylation sARsVsPttEMVsNE
Met MET P08581 human 155,541 T993 3180324 Phosphorylation ARsVsPttEMVsNEs
Met MET P08581 human 155,541 Y1003 448469 Phosphorylation VsNEsVDyRAtFPED
Met MET P08581 human 155,541 S1236 2408901 Phosphorylation MyDkEyysVHNktGA
Met MET P08581 human 155,541 T1355 2424927 Phosphorylation HyVHVNAtyVNVKCV
MKK3 MAP2K3 P46734 human 39,318 S218 448276 Phosphorylation IsGyLVDsVAKtMDA
MKK4 MAP2K4 P45985 human 44,288 S257 447654 Phosphorylation ISGQLVDsIAKtRDA
MST3 STK24 Q9Y6E0 human 49,308 T182 4771563 Phosphorylation FGVAGQLtDtQIkRN
mTOR MTOR P42345 human 288,892 T2473 458288 Phosphorylation PAHKKtGttVPEsIH
NDRG1 NDRG1 Q92597 human 42,835 T346 454245 Phosphorylation GtRsRsHtsEGtRsR
NDRG1 NDRG1 Q92597 human 42,835 T356 454247 Phosphorylation GtRsRsHtsEGtRsR
NDRG1 NDRG1 Q92597 human 42,835 S357 4959724 Phosphorylation tRsRsHtsEGtRsRs
Nur77 NR4A1 P22736 human 64,463 S351 447942 Phosphorylation GRRGRLPsKPKQPPD
p38-alpha MAPK14 Q16539 human 41,293 T180 447970 Phosphorylation RHtDDEMtGyVAtRW
p38-alpha MAPK14 Q16539 human 41,293 Y182 447971 Phosphorylation tDDEMtGyVAtRWYR
p38-delta MAPK13 O15264 human 42,090 Y182 454935 Phosphorylation ADAEMtGyVVtRWYR
p70S6K RPS6KB1 P23443 human 59,140 T250 4753242 Phosphorylation sIHDGtVtHtFCGtI
p70S6K RPS6KB1 P23443 human 59,140 T252 448606 Phosphorylation HDGtVtHtFCGtIEY
p70S6K RPS6KB1 P23443 human 59,140 S441 450015 Phosphorylation sPRRFIGsPRtPVsP
p70S6K RPS6KB1 P23443 human 59,140 T444 448358 Phosphorylation RFIGsPRtPVsPVKF
p90RSK RPS6KA1 Q15418 human 82,723 Y220 472907 Phosphorylation IDHEKKAysFCGtVE
PAK2 PAK2 Q13177 human 58,043 S20 448298 Phosphorylation APPVRMsstIFstGG
PAK2 PAK2 Q13177 human 58,043 T21 11178845 Phosphorylation PPVRMsstIFstGGK
PAK2 PAK2 Q13177 human 58,043 S32 5678057 Phosphorylation tGGKDPLsANHsLkP
PAK2 PAK2 Q13177 human 58,043 S42 7997448 Phosphorylation HsLkPLPsVPEEKKP
PAK4 PAK4 O96013 human 64,072 S474 448023 Phosphorylation kEVPRRKsLVGtPYW
PAK5 PAK7 Q9P286 human 80,745 S602 447773 Phosphorylation KEVPKRKsLVGtPYW
PAR-4 PAWR Q96IZ0 human 36,568 S231 476476 Phosphorylation GRyKsttsVsEEDVS
PHC3 PHC3 Q8NDX5 human 106,162 T609 453712 Phosphorylation ECVRMDRtPPPPtLs
PIK3R1 PIK3R1 P27986 human 83,598 Y467 451144 Phosphorylation SREyDRLyEEytRTS
PIK3R2 PIK3R2 O00459 human 81,545 Y464 449572 Phosphorylation sREyDQLyEEytRTS
PIP5K1A PIP5K1A Q99755 human 62,633 Y360 464013 Phosphorylation PAPQKALySTAMEsI

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