Curated Information

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Curated Information Page

PubMed Id: 16914575

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Miyata Y, Kanetake H, Kanda S (2006) Presence of phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor progression and survival in patients with conventional renal cell carcinoma. Clin Cancer Res 12, 4876-81 16914575

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y1234-p - Met (human)

▲

Orthologous residues

Met (human): Y1234‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: kidney cancer

Relevant cell lines - cell types - tissues: ACHN (renal), epithelial-'kidney, tubule'

Cellular systems studied: cell lines, tissue

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
HGF				increase

Y1235-p - Met (human)

▲

Orthologous residues

Met (human): Y1235‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: kidney cancer

Relevant cell lines - cell types - tissues: ACHN (renal), epithelial-'kidney, tubule'

Cellular systems studied: cell lines, tissue

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
HGF				increase

Y1349-p - Met (human)

▲

Orthologous residues

Met (human): Y1349‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: kidney cancer

Relevant cell lines - cell types - tissues: ACHN (renal), epithelial-'kidney, tubule'

Cellular systems studied: cell lines, tissue

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
HGF				increase

Associated Diseases

Diseases:	Alterations:	Comments:
kidney cancer	increased

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