Curated Information
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PubMed Id: 22445341 
Ultanir SK, et al. (2012) Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development. Neuron 73, 1127-42 22445341
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S281-p - NDR1 (human)
Orthologous residues
NDR1 (human): S281‑p, NDR1 (mouse): S281‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  brain, COS (fibroblast), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cultured cells, tissue
 Species studied:  monkey, mouse, rat
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization
 Comments:  reduction in dendritic branching and length

T444-p - NDR1 (human)
Orthologous residues
NDR1 (human): T444‑p, NDR1 (mouse): T444‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  brain, COS (fibroblast), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cultured cells, tissue
 Species studied:  monkey, mouse, rat
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization
 Comments:  reduction in dendritic branching and length

S277-p - PIK4CB iso2 (human)
Orthologous residues
PIK4CB (human): S277‑p, PIK4CB iso2 (human): S277‑p, PIK4CB (mouse): S277‑p, PIK4CB iso2 (mouse): S277‑p, PIK4CB (rat): S277‑p, PIK4CB iso5 (rat): S277‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NDR1 (mouse)

S635-p - AAK1 (mouse)
Orthologous residues
AAK1 (human): S637‑p, AAK1 iso9 (human): , AAK1 (mouse): S635‑p, AAK1 iso3 (mouse): , AAK1 (rat): S638‑p, AAK1 iso9 (rat):
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NDR1 (mouse)

S514-p - Panx2 (mouse)
Orthologous residues
Panx2 (human): S514‑p, Panx2 (mouse): S514‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NDR1 (mouse)

S307-p - Rab11FIP5 (mouse)
Orthologous residues
Rab11FIP5 (human): S307‑p, Rab11FIP5 (mouse): S307‑p, Rab11FIP5 iso2 (mouse): S342‑p, Rab11FIP5 (rat): S365‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NDR1 (mouse)

S240-p - Rab3IP (mouse)
Orthologous residues
Rab3IP (human): S288‑p, Rab3IP (mouse): S240‑p, Rab3IP (rat): S272‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  brain, COS (fibroblast), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cultured cells, tissue
 Species studied:  monkey, mouse, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NDR1 (mouse)


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