Curated Information
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Curated Information Page
PubMed Id: 22123909 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sanborn KB, et al. (2011) Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity. Blood 118, 5862-71 22123909
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S1943-p - MYH9 (human)
Orthologous residues
MYH9 (human): S1943‑p, MYH9 (mouse): S1943‑p, MYH9 (rat): S1944‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  natural killer cell-blood, YTS
 Cellular systems studied:  primary cells
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Comments:  interacts with lytic granules, colocalized with perforin, and required for NK-cell cytotoxicity


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