Curated Information
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Curated Information Page
PubMed Id: 8940173 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Peterson JE, et al. (1996) Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src. J Biol Chem 271, 31562-71 8940173
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y974-p - IGF1R (mouse)
Orthologous residues
IGF1R (human): Y973‑p, IGF1R (mouse): Y974‑p, IGF1R (rat): Y974‑p, IGF1R (pig): Y973‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, phospho-antibody, phosphoamino acid analysis
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IGF1R (mouse)
KINASE Src (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (mouse) inhibition of upstream enzyme
KINASE IGF1R (mouse) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase

Y981-p - IGF1R (mouse)
Orthologous residues
IGF1R (human): Y980‑p, IGF1R (mouse): Y981‑p, IGF1R (rat): Y981‑p, IGF1R (pig): Y980‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, phospho-antibody, phosphoamino acid analysis
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IGF1R (mouse)
KINASE Src (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (mouse) inhibition of upstream enzyme
KINASE IGF1R (mouse) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase

Y1163-p - IGF1R (mouse)
Orthologous residues
IGF1R (human): Y1161‑p, IGF1R (mouse): Y1163‑p, IGF1R (rat): Y1162‑p, IGF1R (pig): Y1161‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, phospho-antibody, phosphoamino acid analysis
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (mouse)
KINASE IGF1R (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (mouse) inhibition of upstream enzyme
KINASE IGF1R (mouse) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y1167-p - IGF1R (mouse)
Orthologous residues
IGF1R (human): Y1165‑p, IGF1R (mouse): Y1167‑p, IGF1R (rat): Y1166‑p, IGF1R (pig): Y1165‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, phospho-antibody, phosphoamino acid analysis
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (mouse)
KINASE IGF1R (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y1168-p - IGF1R (mouse)
Orthologous residues
IGF1R (human): Y1166‑p, IGF1R (mouse): Y1168‑p, IGF1R (rat): Y1167‑p, IGF1R (pig): Y1166‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, phospho-antibody, phosphoamino acid analysis
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IGF1R (mouse)
KINASE Src (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IGF1R (mouse) genetic knockout/knockin of upstream enzyme
KINASE Src (mouse) inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y1352-p - IGF1R (mouse)
Orthologous residues
IGF1R (human): Y1346‑p, IGF1R (mouse): Y1352‑p, IGF1R (rat): Y1349‑p, IGF1R (pig): Y1346‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, phospho-antibody, phosphoamino acid analysis
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (mouse)
KINASE IGF1R (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IGF1R (mouse) genetic knockout/knockin of upstream enzyme
KINASE Src (mouse) inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase


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