Curated Information
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Curated Information Page
PubMed Id: 12705864 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Sordella R, et al. (2003) Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 113, 147-58 12705864
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Y306-p - ARHGAP5 iso5 (human) ▲
Orthologous residues
ARHGAP5 (human): Y306‑p, ARHGAP5 iso5 (human): Y306‑p, ARHGAP5 (mouse): Y306‑p, ARHGAP5 iso3 (mouse): Y306‑p, ARHGAP5 (rat): Y305‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3-L1 (fibroblast), C2C12 (myoblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE InsR (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell differentiation, altered


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