Curated Information
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Curated Information Page
PubMed Id: 16687578 
Terada Y (2006) Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition. Mol Biol Cell 17, 3232-41 16687578
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K10-m2 - H3 (human)
Orthologous residues
H3 (human): K10‑m2, H3 (mouse): K10‑m2, H3 iso2 (mouse): K10‑m2, H3 iso3 (mouse): K10‑m2, H3 (rat): K10‑m2, H3 iso3 (rat): K10‑m2, H3 (pig): K10‑m2, H3 (chicken): K10‑m2, H3 (cow): K10‑m2
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S11-p - H3 (human)
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA AurB (human) decrease
AurB (human) decrease kinase dead mutant
siRNA INCENP (human) decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  chromatin organization, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
HP1 alpha (human) Disrupts microscopy-colocalization
 Comments:  chromatin organization = cytokinesis progression


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