Curated Information
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Curated Information Page
PubMed Id: 10373534 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ruffner H, et al. (1999) BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol Cell Biol 19, 4843-54 10373534
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S1497-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): S1497‑p, BRCA1 iso6 (human): S393‑p, BRCA1 (mouse): S1454‑p, BRCA1 (rat): S1455‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mass spectrometry, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  HBL-100 (breast cell) [BRCA1 (human)], HBL-100 (breast cell) [CDK2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK2 (human) genetic transfer of dominant-negative enzyme
KINASE CDK2 (human) genetic transfer of wild-type enzyme


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