Curated Information
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Curated Information Page
PubMed Id: 18378770 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Seki A, et al. (2008) Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol 181, 65-78 18378770
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S497-p - BORA (human) ▲
Orthologous residues
BORA (human): S497‑p, BORA (mouse): S458‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) co-immunoprecipitation
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces co-immunoprecipitation
 Comments:  PLK1 phosphorylation of site promotes BORA interaction with, and degradation by, BTRC (SCF-beta-TrCP ligase)

T501-p - BORA (human) ▲
Orthologous residues
BORA (human): T501‑p, BORA (mouse): T462‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) co-immunoprecipitation
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces co-immunoprecipitation
 Comments:  PLK1 phosphorylation of site promotes BORA interaction with, and degradation by, BTRC (SCF-beta-TrCP ligase)


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