Curated Information
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Curated Information Page
PubMed Id: 12447395 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Nakanishi K, et al. (2002) Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol 4, 913-20 12447395
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S222-p - FANCD2 (human) ▲
Orthologous residues
FANCD2 (human): S222‑p, FANCD2 iso2 (human): S222‑p, FANCD2 (mouse): S220‑p, FANCD2 (chicken): S225‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  ataxia-telangiectasia
 Relevant cell lines - cell types - tissues:  ATLD 6 (lymphoblastoid), FA-D2 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  EUFA1020 cells, NBS cells, AT cells.
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
MMC no change compared to control

S222-p - FANCD2 iso2 (human) ▲
Orthologous residues
FANCD2 (human): S222‑p, FANCD2 iso2 (human): S222‑p, FANCD2 (mouse): S220‑p, FANCD2 (chicken): S225‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  ataxia-telangiectasia
 Relevant cell lines - cell types - tissues:  ATLD 6 (lymphoblastoid), FA-D2 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  EUFA1020 cells, NBS cells, AT cells.
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
MMC no change compared to control

S343-p - NBS1 (human) ▲
Orthologous residues
NBS1 (human): S343‑p, NBS1 (mouse): S343‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  ataxia-telangiectasia
 Relevant cell lines - cell types - tissues:  ATLD 6 (lymphoblastoid), FA-D2 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  EUFA1020 cells, NBS cells, AT cells.
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MMC increase
ionizing radiation increase
Downstream Regulation
 Comments:  S343A mutation has no effect on MMC-sensitivity.


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