Curated Information
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Curated Information Page
PubMed Id: 12504004 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sasahara Y, et al. (2002) Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell 10, 1269-81 12504004
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S488-p - WIP (human)
Orthologous residues
WIP (human): S488‑p, WIP (mouse): S478‑p, WIP (rat): S472‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), T lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCT (human) genetic knockout/knockin of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase
rottlerin decrease
Go 6976 no change compared to control
14-22 amide no change compared to control
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
WASP (human) Disrupts cytoskeletal reorganization co-immunoprecipitation


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