Curated Information
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Curated Information Page
PubMed Id: 18194650 
Gavard J, Patel V, Gutkind JS (2008) Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev Cell 14, 25-36 18194650
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S665-p - CDH5 (human)
Orthologous residues
CDH5 (human): S665‑p, CDH5 (mouse): S665‑p, CDH5 (rat): S657‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  skin, SVEC (endothelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiopoietin-1 decrease
VEGF increase
angiopoietin-1 VEGF inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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