Curated Information
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Curated Information Page
PubMed Id: 12456657 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rousseau S, et al. (2002) Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J 21, 6505-14 12456657
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S84-p - hnRNP A0 (mouse) ▲
Orthologous residues
hnRNP A0 (human): S84‑p, hnRNP A0 (mouse): S84‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow, RAW 264 (macrophage)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE MAPKAPK2 (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE MAPKAPK2 (mouse) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase
SB203580 LPS inhibit treatment-induced increase
PD184352 LPS no effect upon treatment-induced increase


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