Curated Information
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PubMed Id: 17897103 
Vanhatupa S, Ungureanu D, Paakkunainen M, Silvennoinen O (2008) MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1. Biochem J 409, 179-85 17897103
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y701-p - STAT1 (human)
Orthologous residues
STAT1 (human): Y701‑p, STAT1 (mouse): Y701‑p, STAT1 (rat): Y701‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [SUMO1 (human)]
 Cellular systems studied:  cell lines
 Species studied:  monkey

S727-p - STAT1 (human)
Orthologous residues
STAT1 (human): S727‑p, STAT1 (mouse): S727‑p, STAT1 (rat): S727‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [SUMO1 (human)]
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE P38A (human) transfection of dominant-negative enzyme, activation of upstream enzyme, pharmacological inhibitor of upstream enzyme
KINASE ERK1 (human) activation of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MKK6 (human) increase
IFN-gamma augment treatment-induced increase augments MKK6-induced increase
SB202190 inhibit treatment-induced increase inhibits MKK6-induced increase
sorbitol increase
SB202190 sorbitol inhibit treatment-induced increase
RAF1 (human) increase
PD98059 inhibit treatment-induced increase inhibits Raf1-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, sumoylation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIAS1 (human) Induces co-immunoprecipitation
 Comments:  enhances STAT1 sumoylation


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