Curated Information
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Curated Information Page
PubMed Id: 22467876 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Kumar P, et al. (2012) Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein 1 (EB1). J Biol Chem 287, 17050-64 22467876
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S499-p - CLASP2 (human)
Orthologous residues
CLASP2 (human): S499‑p, CLASP2 iso3 (human): , CLASP2 iso4 (human): S83‑p, CLASP2 (mouse): S505‑p, CLASP2 iso5 (mouse): , CLASP2 (rat): S505‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
 Comments:  S507 is the priming site

S503-p - CLASP2 (human)
Orthologous residues
CLASP2 (human): S503‑p, CLASP2 iso3 (human): , CLASP2 iso4 (human): S87‑p, CLASP2 (mouse): S509‑p, CLASP2 iso5 (mouse): , CLASP2 (rat): S509‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
 Comments:  S507 is the priming site

S507-p - CLASP2 (human)
Orthologous residues
CLASP2 (human): S507‑p, CLASP2 iso3 (human): , CLASP2 iso4 (human): S91‑p, CLASP2 (mouse): S513‑p, CLASP2 iso5 (mouse): , CLASP2 (rat): S513‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK1 (human)
 Comments:  S507 is the priming site
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization

S541-p - CLASP2 (human)
Orthologous residues
CLASP2 (human): S541‑p, CLASP2 iso3 (human): , CLASP2 iso4 (human): S125‑p, CLASP2 (mouse): S547‑p, CLASP2 iso5 (mouse): , CLASP2 (rat): S547‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK1 (human)
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization


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