Curated Information
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Curated Information Page
PubMed Id: 9171245 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Zhang Y, et al. (1997) Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo. Mol Endocrinol 11, 823-32 9171245
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S162-p - PR (human) ▲
Orthologous residues
PR (human): S162‑p, PR iso2 (human): ‑, PR (mouse): S163‑p, PR (rat): S162‑p, PR (chicken): ‑
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK2 (human)
 Comments:  cyclin A-cdk2 complex phosphorylates hPR-B in vitro
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase

S190-p - PR (human) ▲
Orthologous residues
PR (human): S190‑p, PR iso2 (human): S26‑p, PR (mouse): S191‑p, PR (rat): S190‑p, PR (chicken): ‑
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK2 (human)
 Comments:  cyclin A-cdk2 complex phosphorylates hPR-B in vitro
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase

S400-p - PR (human) ▲
Orthologous residues
PR (human): S400‑p, PR iso2 (human): S236‑p, PR (mouse): S398‑p, PR (rat): S399‑p, PR (chicken): ‑
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK2 (human)
 Comments:  cyclin A-cdk2 complex phosphorylates hPR-B in vitro
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase


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