Curated Information
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Curated Information Page
PubMed Id: 9679146 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Matsuoka Y, Li X, Bennett V (1998) Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. J Cell Biol 142, 485-97 9679146
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S716-p - ADD1 (human)
Orthologous residues
ADD1 (human): S716‑p, ADD1 iso2 (human): , ADD1 iso3 (human): S747‑p, ADD1 (mouse): S714‑p, ADD1 iso2 (mouse): , ADD1 iso3 (mouse): , ADD1 (rat): S714‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, phospho-antibody, mutation in upstream enzyme recognition motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization

S726-p - ADD1 (human)
Orthologous residues
ADD1 (human): S726‑p, ADD1 iso2 (human): , ADD1 iso3 (human): S757‑p, ADD1 (mouse): S724‑p, ADD1 iso2 (mouse): , ADD1 iso3 (mouse): , ADD1 (rat): S724‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, phospho-antibody, mutation in upstream enzyme recognition motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization

S713-p - ADD2 (human)
Orthologous residues
ADD2 (human): S713‑p, ADD2 iso2 (human): , ADD2 (mouse): S712‑p, ADD2 iso2 (mouse): , ADD2 (rat): S712‑p, ADD2 iso2 (rat):
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, phospho-antibody, mutation in upstream enzyme recognition motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization

S726-p - ADD2 (human)
Orthologous residues
ADD2 (human): S726‑p, ADD2 iso2 (human): , ADD2 (mouse): S725‑p, ADD2 iso2 (mouse): , ADD2 (rat): S725‑p, ADD2 iso2 (rat):
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, phospho-antibody, mutation in upstream enzyme recognition motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization

S714-p - ADD1 (rat)
Orthologous residues
ADD1 (human): S716‑p, ADD1 iso2 (human): , ADD1 iso3 (human): S747‑p, ADD1 (mouse): S714‑p, ADD1 iso2 (mouse): , ADD1 iso3 (mouse): , ADD1 (rat): S714‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization

S724-p - ADD1 (rat)
Orthologous residues
ADD1 (human): S726‑p, ADD1 iso2 (human): , ADD1 iso3 (human): S757‑p, ADD1 (mouse): S724‑p, ADD1 iso2 (mouse): , ADD1 iso3 (mouse): , ADD1 (rat): S724‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization

S712-p - ADD2 (rat)
Orthologous residues
ADD2 (human): S713‑p, ADD2 iso2 (human): , ADD2 (mouse): S712‑p, ADD2 iso2 (mouse): , ADD2 (rat): S712‑p, ADD2 iso2 (rat):
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization

S725-p - ADD2 (rat)
Orthologous residues
ADD2 (human): S726‑p, ADD2 iso2 (human): , ADD2 (mouse): S725‑p, ADD2 iso2 (mouse): , ADD2 (rat): S725‑p, ADD2 iso2 (rat):
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial), erythrocyte-blood, MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (cow)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
forskolin no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization


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