|
Orthologous residues
|
|
Myt1 (human): S83‑p, Myt1 (mouse): S74‑p, Myt1 (starfish): S75‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphopeptide mapping
|
|
Relevant cell lines - cell types - tissues:
oocyte [CPEB (mouse)]
|
|
Cellular systems studied:
primary cells
|
|
Species studied:
starfish
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Akt1 (human)
|
transfection of constitutively active enzyme, transfection of inactive enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
1-methyladenine
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
inhibition
|
|
Effect of modification (process):
cell cycle regulation
|
