|
Orthologous residues
|
|
LIMK2 (human): T505‑p, LIMK2 iso2 (human): T484‑p, LIMK2 (mouse): T505‑p, LIMK2 (rat): T505‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site, phosphoamino acid analysis
|
|
Relevant cell lines - cell types - tissues:
COS (fibroblast), HeLa (cervical)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human, monkey
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
ROCK1 (rat)
|
genetic transfer of constitutively active upstream enzyme, inhibition of upstream enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
activation
|
|
Comments:
T505 phosphorylation is also essential for the induction of actin cytoskeletal changes.
|
