Curated Information

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Curated Information Page

PubMed Id: 12624099

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Horike N, et al. (2003) Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J Biol Chem 278, 18440-7 12624099

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S794-p - IRS1 (human)

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Orthologous residues

IRS1 (human): S794‑p, IRS1 (mouse): S789‑p, IRS1 (rat): S789‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	QIK (mouse)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	QIK (mouse)	transfection of inactive enzyme, transfection of constitutively active enzyme, transfection of wild-type enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
insulin				increase

S789-p - IRS1 (rat)

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