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Orthologous residues
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|
Gab2 (human): Y614‑p, Gab2 (mouse): Y603‑p, Gab2 (rat): Y603‑p
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Characterization
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|
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site
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|
Relevant cell lines - cell types - tissues:
293T (epithelial), 293T (epithelial) [Gab2 (human)], 293T (epithelial) [ZAP70 (human)], Jurkat (T lymphocyte)
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|
Cellular systems studied:
cell lines
|
|
Species studied:
human
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Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
ZAP70 (human)
|
transfection of wild-type enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
SHP-2 (human)
|
|
Not reported
|
not reported
|
|
co-immunoprecipitation
|
|
|
Comments:
This site is involved in suppression of T cell activation
|
