Curated Information
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Curated Information Page
PubMed Id: 21982369 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Volpicelli-Daley LA, et al. (2011) Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72, 57-71 21982369
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S129-p - SNCA (mouse)
Orthologous residues
SNCA (human): S129‑p, SNCA (mouse): S129‑p, SNCA (rat): S129‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  neuron-brain
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  embryonic brain
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SNCA (mouse) increase alpha-synuclein preformed fibrils
Downstream Regulation
 Comments:  formation of aggregated SNCA which is ubiquitinated


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