Curated Information

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Curated Information Page

PubMed Id: 10604473

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Bibb JA, et al. (1999) Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 402, 669-71 10604473

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T34-p - DARPP-32 (mouse)

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Orthologous residues

DARPP‑32 (human): T34‑p, DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKACa (mouse)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
roscovitine				increase

T75-p - DARPP-32 (mouse)

▲

Orthologous residues

DARPP‑32 (human): T75‑p, DARPP‑32 (mouse): T75‑p, DARPP‑32 (rat): T75‑p, DARPP‑32 (cow): T75‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'brain, striatum'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
roscovitine				decrease

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