Curated Information
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Curated Information Page
PubMed Id: 21963850 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Huang M, et al. (2012) EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene 31, 2783-93 21963850
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y253-p - P130Cas (mouse) ▲
Orthologous residues
P130Cas (human): Y249‑p, P130Cas (mouse): Y253‑p, P130Cas (rat): Y347‑p, P130Cas iso2 (rat): Y253‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  FG (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (process):  carcinogenesis, induced, cell motility, induced
 Comments:  migration, invasion, metastasis

Y271-p - P130Cas (mouse) ▲
Orthologous residues
P130Cas (human): Y267‑p, P130Cas (mouse): Y271‑p, P130Cas (rat): Y365‑p, P130Cas iso2 (rat): Y271‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  FG (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (process):  carcinogenesis, induced, cell motility, induced
 Comments:  migration, invasion, metastasis

Y424-p - Src (mouse) ▲
Orthologous residues
Src (human): Y419‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  FG (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
MSP increase
IGF-1 increase


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