Curated Information
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Curated Information Page
PubMed Id: 10341243 
Ando K, et al. (1999) Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J Neurosci 19, 4421-7 10341243
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T668-p - APP iso4 (human)
Orthologous residues
APP (human): T743‑p, APP iso4 (human): T668‑p, APP iso8 (human): T724‑p, APP (mouse): T743‑p, APP iso2 (mouse): T668‑p, APP (rat): T743‑p, APP iso2 (rat): T668‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cytoskeletal reorganization
 Comments:  T668E mutant showed decreased neurite extension


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