|
Orthologous residues
|
|
APP (human): T743‑p, APP iso4 (human): T668‑p, APP iso8 (human): T724‑p, APP (mouse): T743‑p, APP iso2 (mouse): T668‑p, APP (rat): T743‑p, APP iso2 (rat): T668‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
electrophoretic mobility shift, immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
PC-12 (chromaffin)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
rat
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
NGF
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
intracellular localization
|
|
Effect of modification (process):
cytoskeletal reorganization
|
|
Comments:
T668E mutant showed decreased neurite extension
|
