Curated Information
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Curated Information Page
PubMed Id: 8413226 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rivera VM, et al. (1993) A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol 13, 6260-73 8413226
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S103-p - SRF (human)
Orthologous residues
SRF (human): S103‑p, SRF (mouse): S99‑p, SRF (rat): S99‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast), Swiss 3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE p90RSK (mouse)
KINASE CAMK2A (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces electrophoretic visualization

S99-p - SRF (mouse)
Orthologous residues
SRF (human): S103‑p, SRF (mouse): S99‑p, SRF (rat): S99‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast), Swiss 3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
serum increase


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