Curated Information

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Curated Information Page

PubMed Id: 22139840

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Barrientos GC, et al. (2012) Gene Dose Influences Cellular and Calcium Channel Dysregulation in Heterozygous and Homozygous T4826I-RYR1 Malignant Hyperthermia-susceptible Muscle. J Biol Chem 287, 2863-76 22139840

S2844-p - RYR1 (mouse)

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Orthologous residues

RYR1 (human): S2843‑p, RYR1 (mouse): S2844‑p, RYR1 (rat): S2840‑p, RYR1 (rabbit): S2843‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'muscle, skeletal'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		RYR1 (mouse)		no change compared to control	RYR1 T4826I knock-in mice

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