|
Orthologous residues
|
|
PPAR‑gamma (human): S273‑p, PPAR‑gamma (mouse): S273‑p, PPAR‑gamma iso2 (mouse): S243‑p, PPAR‑gamma (rat): S273‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
adipose tissue, MEF (fibroblast) [PPAR-gamma (mouse), homozygous knockout]
|
|
Cellular systems studied:
primary cells, tissue
|
|
Species studied:
mouse
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
TNF
|
|
|
|
increase
|
|
|
rosiglitazone
|
TNF
|
|
|
inhibit treatment-induced increase
|
|
|
SR1664
|
TNF
|
|
|
inhibit treatment-induced increase
|
|
|
SR1824
|
TNF
|
|
|
inhibit treatment-induced increase
|
|
|
SR1664
|
|
|
|
decrease
|
in vivo (white adipose tissue)
|
|
