Curated Information

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Curated Information Page

PubMed Id: 21849536

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Matrone C, et al. (2011) APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neurosci 31, 11756-61 21849536

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S473-p - Akt1 (mouse)

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Orthologous residues

Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Disease tissue studied: Alzheimer's disease

Relevant cell lines - cell types - tissues: 'brain, hippocampus' [APP (human), genetic knockin]

Cellular systems studied: primary cells

Species studied: mouse

Comments: APP YG/YG mice

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
NGF				increase

Y757-p - APP (mouse)

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Orthologous residues

APP (human): Y757‑p, APP iso4 (human): Y682‑p, APP iso8 (human): Y738‑p, APP (mouse): Y757‑p, APP iso2 (mouse): Y682‑p, APP (rat): Y757‑p, APP iso2 (rat): Y682‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, microscopy-colocalization with upstream kinase, mutation of modification site, western blotting

Disease tissue studied: Alzheimer's disease

Relevant cell lines - cell types - tissues: 'brain, hippocampus' [APP (mouse), genetic knockin], neuron-'brain, hippocampus' [APP (mouse), genetic knockin]

Cellular systems studied: primary cultured cells, tissue

Species studied: mouse

Comments: APP YG/YG mice

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	TrkA (mouse)	activation of upstream enzyme, microscopy-colocalization, co-immunoprecipitation, pharmacological inhibitor of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
NGF				increase

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