Curated Information
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Curated Information Page
PubMed Id: 21849536 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Matrone C, et al. (2011) APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neurosci 31, 11756-61 21849536
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (mouse)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  'brain, hippocampus' [APP (human), genetic knockin]
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  APP YG/YG mice
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase

Y757-p - APP (mouse)
Orthologous residues
APP (human): Y757‑p, APP iso4 (human): Y682‑p, APP iso8 (human): Y738‑p, APP (mouse): Y757‑p, APP iso2 (mouse): Y682‑p, APP (rat): Y757‑p, APP iso2 (rat): Y682‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, microscopy-colocalization with upstream kinase, mutation of modification site, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  'brain, hippocampus' [APP (mouse), genetic knockin], neuron-'brain, hippocampus' [APP (mouse), genetic knockin]
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  mouse
 Comments:  APP YG/YG mice
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TrkA (mouse) co-immunoprecipitation, microscopy-colocalization, activation of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase


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