Curated Information
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Curated Information Page
PubMed Id: 21804608 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Huertas D, et al. (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31, 1408-18 21804608
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T4-p - H3 (human) ▲
Orthologous residues
H3 (human): T4‑p, H3 (mouse): T4‑p, H3 iso2 (mouse): T4‑p, H3 iso3 (mouse): T4‑p, H3 (rat): T4‑p, H3 iso3 (rat): T4‑p, H3 (pig): T4‑p, H3 (chicken): T4‑p, H3 (cow): T4‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  HCT116 (intestinal), HeLa (cervical), MDA-MB231 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CHR-6494 decrease

S11-p - H3 (human) ▲
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  HCT116 (intestinal), HeLa (cervical), MDA-MB231 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CHR-6494 no change compared to control

S29-p - H3 (human) ▲
Orthologous residues
H3 (human): S29‑p, H3 (mouse): S29‑p, H3 iso2 (mouse): S29‑p, H3 iso3 (mouse): S29‑p, H3 (rat): S29‑p, H3 iso3 (rat): S29‑p, H3 (pig): S29‑p, H3 (chicken): S29‑p, H3 (cow): S29‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  HCT116 (intestinal), HeLa (cervical), MDA-MB231 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CHR-6494 no change compared to control


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